Postoperative pain following laparoscopic cholecystectomy remains a clinically important factor affecting recovery, patient satisfaction, and healthcare utilization. Despite being a minimally invasive procedure, pain is often multifactorial, involving incisional, visceral, and referred components, which makes single-agent analgesia insufficient. This review aimed to provide an updated and integrated overview of pharmacologic and non-pharmacologic strategies for postoperative pain management with an emphasis on multimodal and opioid-sparing approaches. Current evidence supports multimodal analgesia as the most effective strategy for pain control. Pharmacologic management typically includes acetaminophen combined with non-steroidal anti-inflammatory drugs or COX-2 inhibitors, supplemented by selective use of adjuvant agents and local or regional anesthesia techniques. Opioids should be reserved for breakthrough pain and used at the lowest effective dose to reduce the risk of adverse effects, including respiratory depression, nausea, and long-term dependence. Non-pharmacologic interventions such as early mobilization, breathing exercises, transcutaneous electrical nerve stimulation, and structured patient education further enhance recovery by reducing pain perception, anxiety, and functional limitations. Evidence also highlights the importance of individualized pain management based on patient-specific factors such as age, comorbidities, and surgical risk profile. Integration of these strategies within Enhanced Recovery After Surgery (ERAS) pathways improves clinical outcomes, shortens hospital stay, and enhances patient satisfaction. From a clinical perspective, postoperative pain management should shift toward a coordinated, multidisciplinary, and patient-centered approach that prioritizes opioid stewardship and functional recovery. The combination of pharmacologic and non-pharmacologic interventions represents the current standard of care and supports improved perioperative outcomes in laparoscopic cholecystectomy.